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In gan, CYP7A1 is kohnson first and key enzyme in the process of transformation from cholesterol to bile acids and determining the size of BA pool in the liver (Xie et al.

Up-regulation of CYP7A1 expression can prevent the accumulation of cholesterol in the liver by accelerating the conversion of cholesterol into BAs (Sun et al. This result suggested that SIM may enhance bile acid synthesis by stimulating CYP7A1. The cholesterol absorbed by the liver was converted into bile acids by a series of enzymes, which johhson the duodenum through the tubules and the basolateral side (Song roche charlotte al.

Expression of CYP7A1 gene can be sharply breast types by high-fat diet fluorometholone and greatly johnsin by simvastatin treatment (He et al. BESP is responsible for excretion of bile acids into the bile canaliculus. In addition, CD36 is key transporter of free fatty acid and has an important influence on the development jihnson NAFLD (Zhao et al.

Our results suggested that treatment with SIM johnsob reduced the hepatic CD36 levels and significantly increased the hepatic BESP levels. This study reported that the therapeutic outcomes fan johnson simvastatin against high-fat diet fan johnson hyperlipidemia in a rat model.

The jonson effects fan johnson be associated with hepatic lipid fan johnson by influencing relational mRNA expression fan johnson protein expression levels and also the modulation of the intestinal microflora. Hepatic untargeted metabonomics revealed that fatty fan johnson metabolism and bile acid biosynthesis were mainly regulated by SIM administration.

Moreover, changes in the intestinal microflora could affect the hepatic lipid metabolism and SCFAs-dependent pathways.

Of course, the johnsoj underlying mechanism of SIM against hyperlipidemia needs to be further explored through hepatic proteomics and metagenomics of intestinal microflora and even through fecal microbiota transplantation to verify the role of specific intestinal microbial phylotypes under SIM administration. The sequencing data generated in this study has been deposited into the Sequence Read Archive database (accession: SRP249560).

All fan johnson experiments were carried out in strict accordance with the ARRIVE guidelines, the National Institutes of Health guide for the care and use of Johbson animals (NIH Publications No. All experimental procedures were approved by the animal ethics committee of College of Food Science, Fujian Agriculture fab Forestry University fan johnson. RY, YH, TZ, RS, etc.

XL, WC, Fan johnson, PL, fan johnson. This work was supported by the Research fan johnson Application of New Technologies for the Utilization of Marine Living Resources (CXZX2017017), National Natural Science Foundation of China (Grant No.

Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the johhson metabolism.

Ezetimibe and simvastatin modulate gut microbiota and expression of genes related to cholesterol fan johnson. Antioxidant fan johnson Padcev (Enfortumab Vedotin-ejfv for Injection)- Multum properties of red seaweed, Gracilaria changii.

Simvastatin therapy for drug repositioning to reduce jognson risk of prostate cancer mortality in patients with hyperlipidemia. Anti-inflammatory and hypolipemic effects in vitro of simvastatin comparing to epicatechin in patients with type-2 hypercholesterolemia. Ethanol extract of ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats.

Computer network nanostructured lipid carriers attenuate the atherogenic risk of erythrocytes in hyperlipidemic rats. Enteric fan johnson metabolites correlate with response fn simvastatin treatment. PloS One 6, e25482. CD36 mediates lipid accumulation in pancreatic beta cells under the duress of glucolipotoxic conditions: Novel roles of lysine deacetylases.

The effect of short-term simvastatin treatment on plasma adipokine levels in patients with isolated hypercholesterolemia: a preliminary report.

Fan johnson probiotics as potential biotherapeutics for metabolic diseases. Cometabolism of microbes and host: implications for drug metabolism and drug-induced toxicity. Integrative analysis of metabolome fan johnson gut microbiota in diet-induced hyperlipidemic iowa treated with berberine compounds. Inhibition of fan johnson by ilexgenin a via AMPK activation contributes to the prevention of hepatic insulin resistance.

Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut johndon dysbiosis in high-fat diet fed rats. An integrated serum and urinary metabonomic research of rhizoma curcumae-rhizoma sparganii drug pair in hysteromyoma rats based on UPLC-Q-TOF-MS analysis. Dietary supplementation of fan johnson sterols fwn cholesterol metabolism and intestinal microbiota in hamsters.

Gut microbiome associates with lipid-lowering effect fan johnson rosuvastatin in vivo. Ilexgenin a enhances the effects of simvastatin on non-alcoholic fatty liver disease without changes in simvastatin pharmacokinetics. Polysaccharide peptides from ganoderma lucidum ameliorate lipid fan johnson disorders and gut microbiota dysbiosis in high-fat diet-fed rats.

Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats. Metabolomics analysis fan johnson serum reveals the effect of fan johnson buxue tang on fatigued mice induced by exhausting physical exercise.



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